Authors
Xing Wang, Kunyan Dong, Zhichao Wang, Yuqi Tang, Quan Li
Published in
Advanced materials (Deerfield Beach, Fla.). Pages e75395. Oct 15, 2026. Epub Oct 15, 2026.
Abstract
Tumor hypoxia, limited solid-tumor imaging, and insufficient systemic antitumor immunity remain major challenges to effective cancer phototheranostics. Here, a molecular conformation engineering strategy is developed to construct TBBP, which features a strengthened electron donor, a moderately twisted conformation, extended π-conjugation, and a robust molecular skeleton free of labile olefinic π-bridges. TBBP exhibits excellent photostability, broadband second near-infrared (1000-1600 nm) emission, and efficient photothermal conversion (42.17%). Supramolecular assembly with DSPE-PEG2000 affords stable TBBP nanomicelles, TBBP NPs, that selectively generate superoxide radicals (O2 -•) and retain potent Type I photodynamic therapy (PDT) activity under hypoxia. Photoactivated TBBP NPs further induce mitochondrial dysfunction and caspase-3/GSDME-mediated immunogenic pyroptosis, promoting dendritic cell maturation and CD8+ T cell infiltration. In a bilateral 4T1 tumor model, TBBP NPs enable high-contrast second near-infrared (NIR-II) imaging, while synergistic Type I PDT and photothermal therapy elicit systemic antitumor immunity, achieving 92.0% primary tumor inhibition and 47.7% distant tumor inhibition. This work establishes a molecular conformation engineering strategy and extends its functionality through supramolecular assembly, synergistically integrating NIR-II imaging, hypoxia-tolerant Type I phototherapy, and photoimmunotherapy, thereby providing a generalizable molecular design principle for the development of next-generation multifunctional organic phototheranostic agents.
PMID:
42876433
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 15
- Comments 0