Azoimidazolium Salts as a Platform for Persistent Neutral Aminyl Radicals and Mesoionic Carbene Au(I) Complexes as Cell-Permeable Fluorophores.

Authors

Diego Dusso, Osvaldo F López-Saladino, Ixsoyen F Vázquez-Sandoval, Arturo Jiménez-Sánchez, Virginia Gómez-Vidales, Marcos Flores-Álamo, Susana Porcel-García

Published in

Chemistry (Weinheim an der Bergstrasse, Germany). Pages e71809. Oct 14, 2026. Epub Oct 14, 2026.

Abstract

Strategic electronic matching between imidazolium precursors and aryldiazonium salts enables the synthesis of azoimidazolium derivatives via an operationally simple, base-promoted protocol that circumvents the need for column chromatography. The resulting azoimidazolium scaffolds serve as precursors of highly persistent neutral aminyl radicals, which exhibit remarkable stability with negligible decay after 3 weeks in the solid state. Furthermore, these salts were successfully employed as a versatile platform to access novel Au(I)-mesoionic carbene (MIC) complexes. When evaluated in living human glioblastoma A172 cells, these Au(I)-MIC acted as efficient, cell-permeable fluorophores with an unprecedented substituent-governed, dual-channel readout spanning from the green to the red region, governed by donor strength of the peripheral substituents.

PMID:
42875973
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

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