Early measurement of ST2 and REG3α has a prognostic impact in haploidentical transplantation with post-transplant cyclophosphamide.

Authors

Marta Fonseca-Santos, María García-Álvarez, Luis Antonio Corchete Sánchez, Luis A Marín, Francisco Javier Gil-Etayo, Rebeca Maldonado, Ana Isabel Sánchez, Inmaculada Sánchez-Villares, Ana García-Bacelar, Rodrigo Gil-Manso, Alejandro Avendaño, Miriam López-Parra, Mónica Baile, Almudena Cabero, María Luisa Martín-Mateos, Olga López-Villar, Sara Marcos, Ana África Martín, Estefanía Pérez, Mónica Cabrero, Fermín Sánchez-Guijo, Lourdes Vázquez, Ramón García-Sanz, Miguel Alcoceba, Lucía López-Corral

Published in

Haematologica. Oct 15, 2026. Epub Oct 15, 2026.

Abstract

Research on predictive biomarkers in haploidentical SCT (haplo-HSCT) with post-transplant cyclophosphamide (PTCy) remains limited, particularly regarding the critical first week post-infusion. We prospectively evaluated serum ST2, REG3α, and the MAGIC algorithm pre-conditioning and at days 0, +7, +14, and +21 in 81 adult patients undergoing haplo-HSCT with PTCy. ST2 and REG3α surged significantly from pre-conditioning to day 0 (p=0.031 and p.

PMID:
42876307
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

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