Repurposing a polymerization photoinitiator as a self-immolative photodynamic agent for hypoxic cancer therapy.

Authors

Yueya Zhang, Yuxuan Tu, Zhishuo Li, Siyu Li, Fangxin Xu, Luyao Zhou, Biqing Bao, Lianhui Wang

Published in

Chemical communications (Cambridge, England). Oct 14, 2026. Epub Oct 14, 2026.

Abstract

Photodynamic therapy (PDT) is limited by poor tissue penetration, oxygen dependence, and prolonged photosensitivity. A self-immolative near-infrared (NIR) nanoplatform that repurposes a commercial photoinitiator through upconversion-mediated NIR excitation was developed to overcome tumor hypoxia and minimize post-treatment phototoxicity.

PMID:
42876251
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

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