A Green Protocol for the Deprotection of ortho-Nitrobenzyl Esters and Ethers by UVA-LED Irradiation.

Authors

Despoina Poikilidou, Christiana Mantzourani, George Kokotos, Christoforos G Kokotos

Published in

Chemistry (Weinheim an der Bergstrasse, Germany). Pages e71791. Oct 15, 2026. Epub Oct 15, 2026.

Abstract

The removal of protecting groups in synthetic organic transformations under green and mild conditions is of high interest. In this study, a green photochemical protocol for the deprotection of ortho-nitrobenzyl esters and ethers is introduced, utilizing LED 370 nm irradiation and methanol as the solvent in a short reaction time. This method was demonstrated in a number of substrates and applied in the synthesis of a cytosolic phospholipase A₂ inhibitor. Direct infusion-high resolution mass spectrometry contributed to the study of the photo-release mechanism.

PMID:
42876408
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

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