Visible-light-promoted EDA complex enables cascade annulation of 2-vinyloxydiphenylacetylene with thiols and 4-cyanopyridine: facile access to diverse 2,3-difunctionalized benzofurans.

Authors

Chuang Liu, Tong Hu, Tiantian Xu, Min Wang, Pinhua Li

Published in

Chemical communications (Cambridge, England). Oct 15, 2026. Epub Oct 15, 2026.

Abstract

Herein, we report an electron donor-acceptor (EDA) complex-driven strategy for the three-component cascade annulation of 2-vinyloxydiphenylacetylene, thiols, and 4-cyanopyridine, enabling the regioselective synthesis of C-2 α-thiomethylated and C-3 pyridylmethylated benzofuran derivatives. This protocol features high efficiency, no requirement for an external photocatalyst, broad substrate scope with good functional group compatibility and mild reaction conditions. Mechanistic studies indicate a radical pathway featuring regiospecific addition, annulation, and cross-coupling of the in situ-formed radical intermediate, while sequential protonation and deprotonation ultimately drive aromatization.

PMID:
42876318
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.