Phytochemical Profiling, Antioxidant Potential and Antibacterial Activity of Fagraea fragrans Roxb. Flower Extract Against Antibiotic-Resistant Bacteria.

Authors

Kanlayani Charoensopharat, Surachai Rattanasuk, Kitipong Wechgama

Published in

Pakistan journal of biological sciences : PJBS. Volume 29. Issue 8. Pages 401-410.

Abstract

<b>Background and Objective:</b> <i> Fagraea fragrans</i> Roxb. is a medicinal plant traditionally used in herbal medicine; however, information regarding the phytochemical composition and antibacterial activity of its flower extract against antibiotic-resistant bacteria remains limited. This study aimed to investigate the phytochemical constituents, antioxidant capacity and antibacterial activity of <i>F. fragrans</i> Roxb. flower ethanol extract against selected antibiotic-resistant bacterial strains. <b>Materials and Methods:</b> Qualitative phytochemical screening was performed to identify major bioactive compounds in the ethanol extract. Antioxidant activity was assessed using the DPPH radical scavenging assay, while antibacterial activity against clinically important antibiotic-resistant bacteria was evaluated by agar disc diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays. Data (mean±SD, n = 3) were analyzed by one-way ANOVA with Duncan's test using SPSS v20 (p<0.05). <b>Results:</b> Phytochemical analysis revealed the presence of phenolics, flavonoids, alkaloids and terpenoids in the ethanol extract. The extract demonstrated considerable antioxidant activity with strong DPPH radical scavenging capacity. Antibacterial assays showed inhibitory activity against <i>Acinetobacter baumannii</i>, <i>Burkholderia pseudomallei</i>, carbapenem-resistant Enterobacteriaceae (CRE), multidrug-resistant <i>Klebsiella pneumoniae</i> (MDR-K) and <i>Proteus mirabilis</i>, with inhibition zone diameters ranging from 7 to 11 mm. The lowest MIC value was observed against <i>A. baumannii</i> (1.95 mg/mL), while the lowest MBC value was detected against <i>B. pseudomallei</i> (31.25 mg/mL). No detectable antibacterial activity was observed against <i>Enterococcus faecalis</i> and colistin-resistant <i>Pseudomonas aeruginosa</i>. <b>Conclusion:</b> The new findings demonstrated that <i>F. fragrans </i>Roxb. flower extract possesses promising phytochemical constituents with antioxidant and antibacterial properties. The extract may serve as a potential natural source of bioactive compounds for herbal medicine and future antimicrobial applications against antibiotic-resistant bacteria.

PMID:
42876179
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.