Authors
Luong Dinh-Van, Hoang-Anh Nguyen-Cong, Phuong Duong-Minh, Nguyen Tran-Ngoc, Bich-Ngoc T Nguyen
Published in
Respirology case reports. Volume 14. Issue 10. Pages e70783. Epub Oct 13, 2026.
Abstract
The bird's nest sign (BNS) has been described as a sign on chest computed tomography (CT) in various pulmonary diseases. We report a rare case of primary pulmonary B-cell non-Hodgkin lymphoma with plasmacytic differentiation presenting with BNS, mimicking an invasive fungal disease at first. A 61-year-old Vietnamese man with a history of idiopathic thrombocytopenia and splenectomy 3 years prior to admission presented with prolonged dry cough, mild dyspnoea on exertion and chest discomfort for 3 weeks. His laboratory tests were unremarkable, but his chest CT showed bilateral consolidation with the BNS. After an unfavourable response to anti-fungal therapy, the second transthoracic lung biopsy confirmed the diagnosis of primary pulmonary B-cell non-Hodgkin lymphoma with plasmacytic differentiation. This case highlights the importance of considering lymphoma in the differential diagnosis of BNS when infection is excluded and concurrently seeking a confirmatory diagnosis with repeated diagnostic procedures when necessary.
PMID:
42876532
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.
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