A dual-branch CNN-LSTM framework for exploratory classification of colorectal cancer histopathology and hepatocellular carcinoma clinical records.

Authors

Xiaoyan Guo, Jing Lai, Lili Wu, Dianke Chen

Published in

Frontiers in oncology. Volume 16. Pages 1878061. Epub Sep 30, 2026.

Abstract

Colorectal cancer (CRC) and hepatocellular carcinoma (HCC) remain major diagnostic challenges because classification often depends on modality-specific evidence that is stored in separate public datasets. This study evaluates a dual-branch CNN-LSTM framework using two independent and unpaired data sources: colorectal histopathological image patches and structured HCC clinical-biochemical records. The study is therefore positioned as an exploratory investigation of representation learning across heterogeneous medical datasets. The CNN branch extracts spatial and glandular texture features from curated CRC image patches, whereas the LSTM branch treats fixed-order clinical attributes as a structured feature sequence to learn inter-feature dependencies in the HCC records. Under internal public-dataset testing with bootstrap uncertainty estimation, the full CNN + LSTM + MLP framework achieved an accuracy of 0.978 (95% CI, 0.971-0.984), Macro-F1 of 0.977 (95% CI, 0.971-0.984), and Macro OVR AUC of 0.997 (95% CI, 0.996-0.998). Ablation and baseline comparisons showed lower performance for CNN only (accuracy 0.938), LSTM only (0.875), clinical encoder only (0.890), CNN + LSTM (0.966), CNN + clinical MLP (0.958), late fusion (0.952), EfficientNet-B0-style fusion (0.970), ViT-tiny-style fusion (0.960), XGBoost (0.910), random forest (0.900), and logistic regression (0.875). The full model also exceeded the EfficientNet-B0-style baseline in Macro AUC by 0.003 (95% CI, 0.002-0.004; paired bootstrap P = 0.007; McNemar exact P = 0.011). Grad-CAM and SHAP analyses are used to interpret branch-specific decisions, while the findings remain limited to internal public-dataset validation.

PMID:
42876547
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

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