Authors
Hong-Cun Liu, Xiao-Qing Tan, Jia-Hui Sun, Jie Liu, Juan Meng, Li-Fang Yang, Lai Ke-Dao
Published in
Natural product research. Pages 1-10. Oct 15, 2026. Epub Oct 15, 2026.
Abstract
A new isoflavone, brachypterum-isoflavone A (1), eight known isoflavonoids (2-9), and six known coumarins (10-15) were isolated from the stems of Brachypterum eriocarpum (F.C.How) Adema and Sirich. Compounds 7, 11, 12 and 15 were first reported from this plant. Structures were determined by HR-ESI-MS, NMR, and ECD spectroscopy. Compound 1 showed negligible cytotoxicity (cell viability >92% at 50 μmol/L). At 25 μmol/L, TC and TG levels in the compound 1 group were 0.113 and 0.333 mmol/L, respectively, comparable to those of the lovastatin group (0.094 and 0.296 mmol/L). Oil Red O staining confirmed dose-dependent alleviation of lipid droplet accumulation. Network pharmacology predicted HMGCR as a core target, which was subsequently validated by ELISA. Compound 1 dose-dependently reduced HMGCR protein levels, suggesting that the lipid-lowering activity in FFA-treated HepG2 cells is associated with HMGCR inhibition in the mevalonate pathway, though further in vivo studies are needed to validate the underlying mechanism.
PMID:
42878132
Bibliographic data and abstract were imported from PubMed on 16 Oct 2026.
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