Invasive Cryptococcal Meningitis: A Sequelae of Primary Intestinal Lymphangiectasia.

Authors

Jeemin Kwon, Hanlin L Wang, Guy A Weiss, Anthony Myint

Published in

ACG case reports journal. Volume 13. Issue 10. Pages e02360. Epub Oct 14, 2026.

Abstract

Primary intestinal lymphangiectasia (PIL) is a protein-losing enteropathy causing enteric loss of albumin, immunoglobulins, and lymphocytes. Untreated or inadequately monitored PIL may result in secondary immunodeficiency and opportunistic infections. We report a 30-year-old man with a childhood diagnosis of PIL who developed cryptococcal meningoencephalitis. Evaluation revealed secondary immunodeficiency with lymphopenia and hypogammaglobulinemia which was attributed to ongoing protein-losing enteropathy despite absence of gastrointestinal symptoms, supported by hypoalbuminemia and fat-soluble vitamin deficiencies. This is the third reported case of PIL-associated cryptococcal meningitis and the first in a patient with a previously established diagnosis, highlighting consequences of lapsed subspecialty follow-up in adulthood.

PMID:
42877915
Bibliographic data and abstract were imported from PubMed on 16 Oct 2026.

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