Transplant-Free Recovery in Wilson Disease-Associated Acute Liver Failure.

Authors

Hakan Demiröz, Yusuf Bünyamin Ketenci, Mehmet Akca, Ufuk Avcıoğlu, Ahmet Bektaş

Published in

ACG case reports journal. Volume 13. Issue 10. Pages e02358. Epub Oct 14, 2026.

Abstract

Wilson disease-associated acute liver failure carries high mortality without urgent liver transplantation. Diagnosis is challenging when classical signs like Kayser-Fleischer rings are absent. We report a 28-year-old woman presenting with Wilson disease-associated acute liver failure characterized by Coombs-negative hemolytic anemia, profound hyperbilirubinemia, low alkaline phosphatase, and a New Wilson Index score of 14. Despite predicting poor transplant-free survival, she achieved complete clinical and biochemical recovery following aggressive copper-removal therapy using chelation, zinc, therapeutic plasma exchange, and continuous renal replacement therapy. This case demonstrates that early combined extracorporeal liver support can successfully bridge patients to recovery, potentially obviating liver transplantation.

PMID:
42877911
Bibliographic data and abstract were imported from PubMed on 16 Oct 2026.

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