Shifting Burden of Neural Tube Defects from Early-Life Mortality to an Aging Population Living with Disability - China, 1990-2023.

Authors

Yuwei Wu, Xiaoqian Jia, Lingzhang Wang, Xinyue Lin, Yali Zhang, Le Zhang, Zhiwen Li, Zhiyong Zou, Jufen Liu

Published in

China CDC weekly. Volume 8. Issue 38. Pages 1174-1179. Sep 18, 2026.

Abstract

The burden of neural tube defects (NTDs) has declined with folic acid supplementation and fortification, but comprehensive all-age estimates are lacking.
Using data from the Global Burden of Disease Study 2023, we assessed the all-age NTD burden in China during 1990-2023. Incidence, mortality, and disability-adjusted life year (DALY) rates declined significantly, whereas prevalence increased among adults aged ≥50 years and DALY rates increased among those aged ≥75 years, indicating a shift from early-life mortality to disability in an aging population.
Life-course care should combine primary prevention, long-term rehabilitation and multidisciplinary management for people with NTDs.

PMID:
42877557
Bibliographic data and abstract were imported from PubMed on 16 Oct 2026.

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