Emerging Roles of Dystroglycan in Cardiac Remodeling, Fibrosis, and Heart Failure.

Authors

Bhola Shankar Pradhan, Michał Mączewski

Published in

International journal of molecular sciences. Volume 27. Issue 17. Sep 07, 2026. Epub Sep 07, 2026.

Abstract

The dystrophin-glycoprotein complex (DGC) is a structural and signaling network of cardiac muscle. It connects the extracellular matrix to the intracellular cytoskeleton. Dystroglycan, a component of the DGC, plays an essential role in maintaining the integrity of the sarcolemma of cardiac muscle. It contributes to sarcolemma stability, force transmission, mechanotransduction, calcium homeostasis, and cardiomyocyte survival. While the role of dystroglycan signaling is well established in many inherited disorders such as Duchenne muscular dystrophy, it is less studied in acquired heart failure with reduced ejection fraction (HFrEF). Emerging evidence suggests that dystroglycan remodeling may also occur in HFrEF. This review critically analyzes dystroglycan signaling in healthy and failing hearts, with particular emphasis on its emerging role in acquired HFrEF, including cardiac remodeling and fibrosis.

PMID:
42737844
Bibliographic data and abstract were imported from PubMed on 16 Oct 2026.

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