Authors
Cosmin Vasile Obleaga, Polliana Mihaela Leru, Sergiu Marian Cazacu, Alexandru Marin Pascu, Livia Dragonu, Andreea Doriana Stanculescu, Dragos George Popa, Florin-Liviu Gherghina, Dragos Marian Popescu, Ion Vasile, Lidia Boldeanu
Published in
Medicina (Kaunas, Lithuania). Volume 62. Issue 9. Sep 10, 2026. Epub Sep 10, 2026.
Abstract
Background and Objectives: Necrotizing fasciitis (NF) is characterized by rapid and aggressive infection of the subcutaneous tissue and fascia, and a high risk of death in case of delay in diagnosis and treatment. Materials and Methods: This 7-year retrospective study (May 2017-May 2024) evaluated 38 patients with upper- and lower-limb NF admitted to the surgery clinic at the County Emergency Hospital in Craiova, Romania. Results: 21.8% of the confirmed NF cases were monomicrobial; Gram-positive strains were predominant, but Gram-negative strains were also involved. The mortality rate was 28.9%; acute kidney injury appears as the only independent risk factor associated with mortality, although in univariate analysis, septic shock and high NLR and INR values were also factors associated with mortality. An increased resistance rate to antibiotics was recorded, with a 32.7% MDR rate; moderate to high resistance to piperacillin + tazobactam, most cephalosporins, most carbapenems (for Gram-negative strains), and quinolones was noted. Conclusions: Multidisciplinary management, comprising intensive medical support, prompt targeted antibiotic therapy, and immediate surgical intervention, was critical for achieving favorable patient outcomes. Increasing antibiotic resistance may alter the prognosis in patients with NF.
PMID:
42796350
Bibliographic data and abstract were imported from PubMed on 16 Oct 2026.
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