Approach to Thrombocytopenia.

Authors

Tarinee Rungjirajittranon, Adam Cuker

Published in

Hematology/oncology clinics of North America. Oct 15, 2026. Epub Oct 15, 2026.

Abstract

Thrombocytopenia ranges from benign to life-threatening, requiring a systematic evaluation including history, physical examination, peripheral blood smear review, and targeted laboratory testing. Pseudothrombocytopenia must be excluded. Mechanisms of thrombocytopenia include decreased platelet production, decreased survival, and splenic sequestration. In the inpatient setting, clinicians should consider postoperative thrombocytopenia, heparin-induced thrombocytopenia (HIT), other drug-induced thrombocytopenias, extracorporeal device-related causes, infection, and disseminated intravascular coagulation (DIC). In the outpatient setting, selected causes of thrombocytopenia include immune thrombocytopenia, chronic DIC, thrombotic thrombocytopenic purpura (TTP), and myelodysplastic syndrome, among others. Early recognition and prompt management of life-threatening conditions such as HIT and TTP is critical.

PMID:
42881034
Bibliographic data and abstract were imported from PubMed on 16 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.