Epigenetic mechanisms in brain development and in neurodegeneration.

Authors

Yiyi Ma, Kevin W Chen, Philip DE Jager

Published in

Handbook of clinical neurology. Volume 219. Pages 361-380.

Abstract

Epigenetic mechanisms are important heritable modifications beyond genetic mechanisms. Interindividual epigenetic variants can lead to phenotypic variations even in identical genotypes. Studies on the epigenetic contributions to Alzheimer disease and other neurodegenerative diseases could provide more comprehensive and precise insights into the heritable and nonheritable mechanisms. This knowledge will enable the development of individually tailored preventive and therapeutic pharmacologic interventions. This chapter is divided into three sections. First, we provide a detailed introduction to four epigenetic mechanisms: DNA methylation, histone modifications, chromatin remodeling, and microRNAs. Next, we review published studies that explore the contributions of these epigenetic modifications to Alzheimer disease. Finally, we summarize the current understanding of each epigenetic modification and its influence on the development of the central nervous system.

PMID:
42880847
Bibliographic data and abstract were imported from PubMed on 16 Oct 2026.

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