Authors
A S Kontorshchikov, M U Gushchin, A L Cherniaev, Zh R Omarova, J M Vorontsova, A K Konyukova, V V Pechnikova, L M Mikhaleva
Published in
Arkhiv patologii. Volume 88. Issue 5. Pages 23-28.
Abstract
Since the COVID-19 pandemic, numerous articles have appeared on clinical changes in organs and systems in individuals with humoral immunity to the SARS-CoV-2 virus. However, there is a lack of data on a comprehensive clinical and morphological study of a group of patients with acquired immunity.
To compare lung pathology with humoral immunity data to the SARS-CoV-2 virus in patients who died from a new coronavirus infection with elevated serum Ig class G and M levels and negative PCR.
An analysis of clinical, laboratory, and pathomorphological changes was conducted in 33 autopsy observations of patients who died during the first half of 2021 in the specialized non-infectious departments of the City Clinical Hospital No. 31 named after Academician G.M. Savelyeva with an elevated content of serum Ig class G and M in the blood.
Despite the negative PCR, elevated concentrations of Ig to SARS-CoV-2 proteins were detected in the blood of patients: IgG 0.31 - 532.56 OCE (Me 109.33 OCE), IgM 0.14 - 16.8 U / ml (Me 0.62 IU / ml). At an IgG concentration of 0.31-109.33 OCE in the lungs, an exudative phase of diffuse alveolar damage (DAD) was described, in the IgG range of 122.57-158.72 OCE, exudative-proliferative DAD was described, at IgG values 207.2-532.56 OCE, the proliferative phase of DAD occurred.
The study revealed a sequence of pathological changes in the lungs, depending on the serum IgG concentration, characteristic of DAP. The findings confirm the multifaceted nature of the novel coronavirus infection.
PMID:
42885416
Bibliographic data and abstract were imported from PubMed on 16 Oct 2026.
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