Reproductive-age status and intracranial hypertension in women with cerebral venous thrombosis: a retrospective cohort study.

Authors

Lu Liu, Chunxiao Lu, Ran Duan, Zilin Xu, Hui Li, Xiaoming Zhang, Yifan Zhou, Weiyue Zhang, Huimin Jiang, Xunming Ji, Chen Zhou

Published in

Neurological research. Pages 1-10. Oct 16, 2026. Epub Oct 16, 2026.

Abstract

Cerebral venous thrombosis (CVT) predominantly affects reproductive-age women, but the relationship between reproductive-age status and intracranial hypertension (IH) phenotype remains unclear.
We performed a retrospective cohort study of consecutive female patients with first-ever acute or subacute CVT treated at a tertiary stroke center between September 2014 and March 2023. Patients were stratified into reproductive-age (18-45 years) and non-reproductive-age (>45 years) groups. Clinical characteristics, imaging findings, and 12-month outcomes were compared between groups.
A total of 182 women with CVT were included, comprising 122 of reproductive age. Reproductive-age women were more likely to present with IH at admission compared with their non-reproductive-age counterparts (59.0% vs. 41.7%, p = 0.027). In the overall female cohort, reproductive-age status (adjusted odds ratio [aOR], 1.96; 95% confidence interval [CI], 1.00-3.84; p = 0.049) and superior sagittal sinus involvement (aOR, 2.73; 95% CI, 1.36-5.48; p = 0.005) were independently associated with IH. Within the reproductive-age subgroup, superior sagittal sinus involvement (aOR, 3.00; 95% CI, 1.25-7.21; p = 0.014) and left lateral sinus system involvement (aOR, 3.21; 95% CI, 1.37-7.56; p = 0.007) were independently associated with IH. Although overall functional outcomes at follow-up were similar, residual visual impairment was significantly more frequent in reproductive-age women with IH.
Among women with CVT, reproductive-age status is associated with a greater likelihood of IH. In reproductive-age women, superior sagittal sinus and left lateral sinus system involvement were independently associated with IH, although the laterality-specific finding requires further validation.

PMID:
42886155
Bibliographic data and abstract were imported from PubMed on 16 Oct 2026.

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