Authors
Edward Dababneh, Patrick Brown, Waheed Ahmad, Matthew Rowe, Jamie Callanan, Paul A Gould
Published in
JACC. Case reports. Pages 110628. Oct 16, 2026. Epub Oct 16, 2026.
Abstract
Leadless cardiac resynchronization combining WiSE system ultrasound-mediated left ventricular pacing with leadless right ventricular pacing has been reported. However, atrioventricular-sequential left ventricular pacing triggered by atrial leadless pacing impulse without right ventricular pacing has not been reported.
An 86-year-old man with complete heart block and cardiomyopathy received a dual-chamber leadless pacemaker (AVEIR DR) with WiSE left ventricular endocardial electrode on the septal wall. A novel "sync-to-pace" delay configuration enabled the atrial pacing impulse to trigger left ventricular stimulation, achieving a QRS duration of 142 ms.
This case demonstrates proof of concept for a fully leadless atrioventricular-synchronized system capable of delivering left ventricular septal endocardial pacing without right ventricular pacing dependency, offering a physiological pacing strategy for selected patients.
First-in-human demonstration of an ultrasound-mediated left ventricular endocardial electrode triggered by an atrial leadless pacing impulse to deliver atrioventricular-sequential left ventricular septal stimulation without right ventricular pacing.
This novel totally leadless architecture is a proof of concept for a more physiological pacing option for pacing-dependent patients while avoiding transvenous lead-related complications.
PMID:
42886148
Bibliographic data and abstract were imported from PubMed on 16 Oct 2026.
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