Advanced biomaterial technologies for neural regeneration in central nervous system diseases: mechanisms and applications.

Authors

Denale Anniwa, Zexuan Chen, Xinglv Chen, Wenlong Yuan, Hui Lang, Ning Chen, Ni Zhang, Meng Qin

Published in

Nanoscale. Oct 16, 2026. Epub Oct 16, 2026.

Abstract

Effective repair of central nervous system (CNS) injuries remains highly challenging due to several formidable barriers, including severe structural disruption, hostile microenvironments, and limited intrinsic regenerative capacity. In response, biomaterials incorporated with therapeutic agents provide advanced interventional strategies for neural regeneration. This review systematically summarizes recent progress in biomaterial-based CNS repair, focusing on three core strategies: physical remodeling of the neural structure, targeted drug delivery systems for biochemical regulation, and cellular intervention. Furthermore, we critically analyze the manufacturing and regulatory bottlenecks currently impeding clinical translation. Finally, we propose the integration of neural organoids and brain-computer interface (BCI) technologies as a promising trajectory for next-generation intelligent neural repair materials.

PMID:
42886472
Bibliographic data and abstract were imported from PubMed on 17 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.