Virilizing Juvenile Granulosa Cell Tumor in a Prepubertal Girl with Bilateral Inguinal Hernias: A Case Report.

Authors

Phattariya Yaisilp, Nattakarn Numsriskulrat

Published in

Journal of pediatric and adolescent gynecology. Oct 16, 2026. Epub Oct 16, 2026.

Abstract

Juvenile granulosa cell tumors usually cause estrogenic precocious puberty; virilization is rare.
After staged herniotomies for bilateral inguinal hernia, a 4-year-old girl was noted to have pubic hair, clitoromegaly, adult-type body odor, bilateral breast enlargement, a large pelvic mass, and vaginal bleeding. Gonadotropins were suppressed, while estradiol, testosterone, anti-Müllerian hormone, inhibin A, and CA 125 were elevated. Imaging showed a left adnexal mass with ascites. Left oophorectomy confirmed stage IA juvenile granulosa cell tumor. Sex steroids normalized within 7 days after surgical removal of tumor, and anti-Müllerian hormone declined.
Coexisting estrogenic and androgenic signs should prompt evaluation for juvenile granulosa cell tumors, particularly in children with a pelvic mass.

PMID:
42887639
Bibliographic data and abstract were imported from PubMed on 17 Oct 2026.

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