Authors
Anna Roberts, Carmen Andreescu, Ann Cohen, Neelesh K Nadkarni, Davneet Minhas, Charles Laymon, Brian Lopresti, Beth Snitz, Helmet T Karim
Published in
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. Sep 22, 2026. Epub Sep 22, 2026.
Abstract
Default mode network (DMN) structures, including hippocampus, accumulate amyloid-beta and tau pathology in Alzheimer's disease (AD) and display connectivity changes prior to the onset of cognitive dysfunction.
We recruited cognitively healthy older adults who underwent PiB and AV1451 imaging and resting state functional imaging. We evaluated nonlinear associations between hippocampal DMN connectivity and amyloid-beta and tau in cross-sectional analyses.
Left and right anterior hippocampal to DMN intranetwork connectivity was greater with greater amyloid and was lower with even greater levels of amyloid (inverted U-shape association). We found that inter-network hippocampal connectivity was greater with greater amyloid and tau. Greater intra and inter-DMN connectivity was associated with greater cognitive function especially memory and attention, consistent with protective association processes.
Intranetwork DMN connectivity was greater with low to moderate amyloid and was lower with greater amyloid and tau in preclinical AD-connectivity may help maintain cognitive function, especially memory. Functional connectivity may potentially offset the impact of early amyloid and tau accumulation and transitionally spare cognitive function.
PMID:
42888083
Bibliographic data and abstract were imported from PubMed on 17 Oct 2026.
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