Behavior-metabolism-autophagy axis in ticks and mosquitoes.

Authors

Jéssica C T Pereira, Maria Elisa Lima, Yago Sassi, Bruno Moraes, Satoru Konnai, Tomohiro Okagawa, Itabajara da Silva Vaz, Isabela Ramos, Carlos Logullo

Published in

Trends in parasitology. Oct 16, 2026. Epub Oct 16, 2026.

Abstract

Hematophagous arthropods, including mosquitoes and ticks, experience marked fluctuations in nutrient availability that shape survival, reproduction, and development. Despite their distinct life histories, both groups adjust behavior, endocrine signaling, metabolism, and cellular maintenance in response to nutrient availability. Autophagy is a conserved recycling pathway that may link cellular energy status to tissue remodeling, reproduction, and development. In this review, we examine evidence from mosquitoes and ticks through the behavior-metabolism-autophagy axis, exploring potential links among behavioral responses, metabolic allocation, and intracellular recycling under fluctuating nutritional conditions. Mosquitoes provide the strongest mechanistic evidence, whereas mechanistic studies in ticks remain limited. This comparative review highlights current evidence and key questions for future work.

PMID:
42888051
Bibliographic data and abstract were imported from PubMed on 17 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.