Advances in light-addressable potentiometric sensors: A review of structures and materials, detection mechanisms, systems, and multi-scenario applications.

Authors

Jie Tan, Guomao Yan, Shibin Liu, Bin Sun, Zijie Tang, Jiangze Ren, Yinghao Chen, Guifang Li, Xueliang Li, Dong Chen

Published in

Analytica chimica acta. Volume 1424. Pages 346115. Nov 22, 2026. Epub Aug 17, 2026.

Abstract

Light-addressable potentiometric sensor (LAPS) technology has emerged as a promising approach for biochemical reaction monitoring owing to its distinctive advantages, including label-free detection, non-invasive operation, and real-time visualization. This paper begins by introducing the working principle and basic structure of LAPS, and then systematically summarizes recent advances in improving its key performance metrics, particularly detection sensitivity and spatiotemporal resolution, from three perspectives: device structures and materials, detection mechanisms, and detection systems. Furthermore, representative applications of LAPS in biochemical detection are comprehensively reviewed. Finally, the limitations and future perspectives for the development of LAPS are discussed.

PMID:
42888000
Bibliographic data and abstract were imported from PubMed on 17 Oct 2026.

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