Neurovascular coupling in simultaneous EEG-fNIRS studies: A scoping review of analytical frameworks and clinical applications.

Authors

Wsu Yu, Rajamanickam Yuvaraj, Stephane Perrey, Hasan Ayaz, Wei-Peng Teo

Published in

NeuroImage. Pages 122298. Oct 16, 2026. Epub Oct 16, 2026.

Abstract

Simultaneous electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) have been used across cognitive and physiological states and in diverse clinical populations. However, the interpretation of cross-modal coupling remains difficult because findings from different analytical frameworks, populations, and experimental conditions have not been systematically mapped. This scoping review followed the Arksey and O'Malley framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). PubMed, Scopus, Web of Science, EBSCO, and IEEE Xplore were searched through February 10, 2026, for studies that quantitatively related simultaneously recorded EEG and fNIRS signals. Two reviewers independently screened the records. Findings were synthesized narratively, and analytical pipelines were mapped across the signal domain, feature extraction, coupling metric, and temporal lag handling. Fifty-seven studies were included. Amplitude-based studies related event-related potentials and oscillatory EEG features to focal hemodynamic responses, with associations varying across electrophysiological features, cortical regions, and task conditions. Frequency- and scale-specific analyses identified band-dependent relationships, while coupling at ultra-slow scales showed sensitivity to vascular and systemic physiological influences. Studies that explicitly modeled timing identified several-second offsets in some paradigms, while directional estimates varied across tasks and recording states. Network analyses showed partial and context-dependent correspondence between EEG- and fNIRS-derived measures, while model-based approaches characterized multivariate and predictive cross-modal relationships. Across frameworks, observed coupling differed with recording state, frequency band, cortical region, and temporal lag handling rather than representing a single quantity. Clinical findings were heterogeneous, and most condition-specific patterns were supported by small and methodologically diverse evidence bases. These findings support framework-matched analysis and pipeline-explicit reporting when interpreting EEG-fNIRS coupling.

PMID:
42887838
Bibliographic data and abstract were imported from PubMed on 17 Oct 2026.

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