Authors
Mingzhu Dai, Ying He, Zhaofeng Gu, Yuxuan Xu, Yuyang Xia, Longfei Du, Bohang Su, Shixiong Wang, Huiping Bai
Published in
Analytica chimica acta. Volume 1424. Pages 346243. Nov 22, 2026. Epub Sep 09, 2026.
Abstract
Estrogens, as typical endocrine-disrupting compounds, pose potential risks to ecological safety and public health even at trace levels, making the development of highly sensitive detection methods crucial. In this work, a flexible electrochemical sensor was developed for the highly sensitive dual detection of 17β-estradiol (E2) and estriol (E3). A three-electrode system of three-dimensional porous laser-induced graphene (LIG) was directly fabricated on a flexible polyimide substrate via laser writing and further modified with a Pr/Zn metal-organic framework (MOF). MOF modification shifted the electrode process from diffusion-controlled to adsorption-controlled, significantly enhancing the enrichment of target molecules, while the 3D porous LIG provided abundant active sites and rapid electron transport channels. The synergistic effect of these two components substantially improved sensor sensitivity. The sensor exhibited linear detection ranges of 1 × 10-9 to 5 × 10-6 mol L-1 for E2 and 1 × 10-8 to 5 × 10-6 mol L-1 for E3, with detection limits as low as 3.5 × 10-10 mol L-1 and 3.5 × 10-9 mol L-1, respectively. It also demonstrated excellent anti-interference performance, reproducibility, and long-term stability, achieving recoveries of 92%-111% in spiked real-sample tests. The combination of superior electrochemical performance and flexible substrate integration provides a promising strategy for designing flexible and portable platforms for on-site trace estrogen monitoring.
PMID:
42887985
Bibliographic data and abstract were imported from PubMed on 17 Oct 2026.
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