Target Trial Emulation or Target Trial Approximation?

Authors

Priya Vart

Published in

Pharmacoepidemiology and drug safety. Volume 35. Issue 11. Pages e70485.

Abstract

Target trial emulation has contributed to improvements in the design and interpretation of observational studies aimed at causal inference. By encouraging researchers to think explicitly about the design of a hypothetical randomized trial, it has helped identify and address avoidable design flaws. However, the framework cannot overcome biases and limitations inherent in observational data. Despite the aim of emulating a randomized trial, observational data cannot reproduce random treatment assignment or blinding, and may not necessarily provide greater generalizability than a randomized trial. Thus, the term "emulation" may imply a degree of similarity to a randomized trial that observational data cannot realistically achieve and deserves critical reconsideration to better reflect the limitations of observational data.

PMID:
42888900
Bibliographic data and abstract were imported from PubMed on 17 Oct 2026.

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