Small Cell Neuroendocrine Carcinoma of the Bladder With Lymph Node Metastases: A Case Report.

Authors

Souad El Ourdi, Othmane Zouiten, Leila Afani, Mohamed El Fadli, Rhizlane Belbaraka

Published in

Cureus. Volume 18. Issue 9. Pages e116353. Epub Sep 16, 2026.

Abstract

Small cell neuroendocrine carcinoma (SCNEC) of the bladder accounts for less than one percent of all bladder cancers and is a highly aggressive and rare tumor. Rapid progression, early metastatic spread, and generally poor prognosis are the defining characteristics. Although there is currently no standardized therapeutic consensus, management is based on a multimodal approach that combines systemic chemotherapy, surgery, and/or radiotherapy. In this report, we report the case of a 62-year-old female patient who presented with metastatic neuroendocrine bladder cancer involving the lymph nodes, evidenced by the presence of inguinal lymphadenopathy. To confirm the tumor's neuroendocrine nature, the patient underwent transurethral resection of the bladder tumor (TURBT) with placement of double-J ureteral stents. First-line chemotherapy with etoposide and carboplatin was subsequently initiated. The histological rarity of neuroendocrine bladder carcinoma underscores the uniqueness of this case.

PMID:
42891345
Bibliographic data and abstract were imported from PubMed on 18 Oct 2026.

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