Hematologic Malignancies With RUNX1::ZFPM2 Translocation: A Case Report and Literature Review.

Authors

Marie Temple, Romain Vazquez, Estelle Balducci, Lucile Couronné, Rudy Birsen, Anne-Laure Roupie, Justine Decroocq, Cyrielle Rodier, Lise Willems, Nicolas Chapuis, Carole Almire, Ismaël Boussaid, Michaela Fontenay, Didier Bouscary, Olivier Kosmider, Chloé Friedrich

Published in

EJHaem. Volume 7. Issue 5. Pages e70395. Epub Oct 16, 2026.

Abstract

RUNX1 rearrangements are recurrent in myeloid neoplasms, but rare fusion partners remain poorly characterized. We report the first acute myeloid leukemia (AML) with a RUNX1::ZFPM2 fusion generated by t(8;21)(q23;q22). A 72-year-old woman presented with acute myelomonocytic leukemia carrying concomitant IDH2 and NRAS mutations. Azacitidine-venetoclax induced transient remission with a marked decrease in the fusion transcript. However, persistent cytopenias, molecular relapse, and treatment resistance led to death 1 year after diagnosis. This case expands the spectrum of RUNX1-rearranged AML and suggests a biological behavior distinct from classical RUNX1::RUNX1T1-positive AML.
The authors have confirmed clinical trial registration is not needed for this submission.

PMID:
42890877
Bibliographic data and abstract were imported from PubMed on 18 Oct 2026.

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