Loss of the Orphan GPCR srd-44 Does Not Alter Chemotaxis of Caenorhabditis elegans to Carolina Mantle Slug Mucus.

Authors

Jay Garaycochea, Milo Roth

Published in

microPublication biology. Volume 2026. Epub Oct 03, 2026.

Abstract

C. elegans detect volatile odorants through amphid sensory neurons that express diverse G protein-coupled receptors (GPCRs), many of which remain functionally uncharacterized. We evaluated the candidate chemosensory GPCR srd-44 using the RB1526 mutant strain in chemotaxis assays against diacetyl and Carolina mantle ( Philomycus carolinianus ) slug mucus. Wild-type and mutant animals exhibited similar chemotaxis responses to both stimuli across a range of concentrations. Under these conditions, these results do not support a role for srd-44 in chemotaxis toward diacetyl or Carolina mantle slug mucus. These findings contribute to the functional evaluation of an orphan chemosensory GPCR in C. elegans .

PMID:
42892891
Bibliographic data and abstract were imported from PubMed on 18 Oct 2026.

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