Authors
Asiya Abudesimu, Zhonghua Sun, Ge Zhang, Xiangyu Sun, Xinliang Peng, Dilixiati Siti, Xiang Ma
Published in
Science progress. Volume 109. Issue 4. Pages 368504261499186. Epub Oct 18, 2026.
Abstract
ObjectiveTo assess the association of the endothelial activation and stress index (EASIX) with all-cause and cardiovascular mortality in adults at cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3.MethodsThis retrospective analysis of a population-based cohort included 10,885 adults aged ≥30 years from NHANES 1999-2018, with mortality follow-up through 2019. EASIX was calculated as lactate dehydrogenase × creatinine/platelet count. Survey-weighted Cox models, restricted cubic splines, subgroup analyses and sensitivity analyses evaluated mortality associations.ResultsDuring a median follow-up of 97 months, 1,122 participants died, including 295 from cardiovascular causes. Each one-unit increase in EASIX was associated with all-cause mortality (adjusted hazard ratio [HR] 1.41, 95% confidence interval [CI] 1.24-1.61) and cardiovascular mortality (HR 1.30, 95% CI 1.13-1.49). There was no evidence of non-linearity for all-cause mortality (P = 0.466), while the cardiovascular association was non-linear (P = 0.008). Associations persisted after additional lifestyle adjustment. CKM-stage interactions were not significant in the full cohort.ConclusionsHigher EASIX was associated with greater all-cause and cardiovascular mortality in CKM stages 0-3. Its potential role in clinical risk assessment warrants further validation.
PMID:
42893432
Bibliographic data and abstract were imported from PubMed on 18 Oct 2026.
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