Authors
Tracey Couse, Askiel Bruno, Terri Marin
Published in
Biological research for nursing. Pages 10998004261496520. Oct 18, 2026. Epub Oct 18, 2026.
Abstract
Remote ischemic conditioning (RIC) is a promising noninvasive intervention that may enhance endogenous cerebroprotective mechanisms following ischemic stroke. Although clinical studies suggest potential benefits, the physiological mechanisms underlying RIC remain incompletely understood, particularly whether RIC-associated hemodynamic changes are accompanied by changes in cerebral tissue oxygenation. No conceptual framework currently integrates these relationships to guide future research. The purpose of this paper is to present the Cerebral Oxygenation-Conditioning Response (CO-CoRe) Framework, a mechanistic conceptual framework describing the hypothesized relationships among RIC, compensatory cerebral blood flow, cerebroprotection, and cerebral regional oxygen saturation (CrSO₂) following ischemic stroke. The CO-CoRe Framework integrates evidence-supported relationships among RIC, compensatory cerebral blood flow, and cerebroprotection with a hypothesized relationship between RIC and CrSO2, providing a mechanistic foundation for examining cerebral tissue oxygenation following ischemic stroke. By synthesizing current evidence on ischemic conditioning, cerebrovascular physiology, and cerebral tissue oxygenation, the CO-CoRe Framework generates testable hypotheses and provides a foundation for future research evaluating CrSO₂, measured using near-infrared spectroscopy, as a physiological response to RIC. Ultimately, the framework may advance understanding of RIC-associated cerebroprotection and inform physiologic monitoring strategies in ischemic stroke.
PMID:
42893384
Bibliographic data and abstract were imported from PubMed on 18 Oct 2026.
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