Fibrinolytics in the Management of Complex Abdominal Collections: a case report and review of the literature.

Authors

Sultan Almuallem

Published in

Oxford medical case reports. Volume 2026. Issue 10. Pages omag197. Epub Oct 17, 2026.

Abstract

Complex intra-abdominal collections typically present management challenges, with percutaneous drainage remaining the standard of care. Fibrinolytic therapy has limited data for complex intra-abdominal collections despite solid evidence in intrapleural empyema. Here, we report a case of successful fibrinolytic therapy in a patient with persistent intra-abdominal collection. A 57-year-old woman with a history of open Roux-en-Y gastric bypass presented with a perforated marginal ulcer. Following successful surgical management, she developed a recurrent/persistent intra-abdominal collection that failed several percutaneous drainage attempts. Alteplase was administered through the abdominal drain, resulting in complete resolution of the collection. Despite limited evidence, fibrinolytic therapy for complex abdominal collections appears applicable and safe in selected cases. Further large series and randomized trials are needed to examine its efficacy and cost-effectiveness.

PMID:
42893119
Bibliographic data and abstract were imported from PubMed on 18 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.