Authors
Weiwei Fang, Fengliang Lu, Xin Li, Meng Wang, Xiying Li
Published in
Journal of blood medicine. Volume 17. Pages 637147. Epub Oct 14, 2026.
Abstract
Human platelet antigens (HPA) are clinically significant in transfusion refractoriness, but whether HPA genotypes are associated with cumulative donation frequency or apheresis yield remains unknown.
We genotyped 1,242 platelet apheresis donors from Harbin, China for eight HPA systems (HPA-1, -2, -3, -4, -5, -6, -15, and -21). Outcomes were cumulative donation count and index yield (0.5/1/2 units). Univariate analyses used Kruskal-Wallis and Mann-Whitney tests. Multivariable negative binomial and binary logistic regressions adjusted for age, sex, ABO, and ethnicity. Sensitivity analyses excluded first-time donors, stratified by age, and removed the top 5% of donors.
HPA-3 and HPA-15 were the most polymorphic (b-allele frequencies: 42.0% and 44.5%). However, neither HPA-3 nor HPA-15 was significantly associated with cumulative donation count in multivariable negative binomial regression (HPA-15 ab vs aa+bb: IRR=1.02, 95% CI: 0.90-1.15, P=0.79; HPA-3 b carrier vs aa: IRR=0.97, 95% CI: 0.85-1.10, P=0.66). Similarly, no significant association was found between HPA-15 b carrier status and apheresis yield (OR=0.97, 95% CI: 0.76-1.25, P=0.83). These null findings remained consistent across all sensitivity analyses.
In this cohort of northern Chinese Han platelet apheresis donors, HPA genotypes-including the polymorphic HPA-3 and HPA-15 systems-were not significantly associated with donation frequency or apheresis yield.
PMID:
42894787
Bibliographic data and abstract were imported from PubMed on 19 Oct 2026.
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