Federated Time-to-Event Data Analysis Using Piecewise Exponential Regression in DataSHIELD.

Authors

Bodil Svennblad, Benedicte Delcoigne, Paul Burton, Demetris Avraam

Published in

Statistics in medicine. Volume 45. Issue 23-24. Pages e70789.

Abstract

Time-to-event analyses on individual patient data are commonly performed with Cox or Poisson regression. The statistical power of epidemiological findings from such analyses is often sufficient when a large amount of data is analyzed, especially when studying rare outcomes or rare exposures. The increase of sample size can be achieved by co-analyzing data collected from different cohorts and hosted at different locations. For co-analyzing data located at different centers, the common options are either (i) to physically transfer and pool the data into a single dataset and analyze them jointly or (ii) to conduct a two-step meta-analysis where a separate analysis is done at each center and the center-specific results are then pooled and combined into a single estimate. DataSHIELD offers a third option where individual patient data from different locations are analyzed in a federated manner without transporting any data. In this paper, we describe how a federated Poisson regression can be conducted on time-to-event data using this infrastructure, providing relevant estimates.

PMID:
42894295
Bibliographic data and abstract were imported from PubMed on 19 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.