Bioactive components from Sinomenium acutum exhibit anti-inflammatory activity and sensitize cervical cancer cells to paclitaxel.

Authors

Xilei Wang, Chengjing Zhu, Xinyu Du, Qiang Wang, Jianqing Yu

Published in

Natural products and bioprospecting. Volume 16. Issue 1. Oct 19, 2026. Epub Oct 19, 2026.

Abstract

Six previously undescribed compounds, together with twelve known compounds, were isolated from Sinomenium acutum. The structures of the unreported compounds were determined by comprehensive spectroscopic data analysis, ¹³C NMR calculations followed by DP4 + analysis, ECD calculations, and single-crystal X-ray diffraction analysis. Nine compounds exhibited more potent anti-inflammatory activities than the positive control indomethacin. The structure-activity relationship of the isolates with anti-inflammatory effects was elucidated, providing some useful clues for designing and developing structurally novel anti-inflammatory drugs. Furthermore, five compounds reversed the paclitaxel resistance in paclitaxel-resistant cervical cancer cells HeLa/PTX. The combination of compound 4 and paclitaxel promoted cancer cell apoptosis.

PMID:
42895598
Bibliographic data and abstract were imported from PubMed on 20 Oct 2026.

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