Therapy for kidney vasculitis in children during the acute phase and maintenance: updates and insights from new adult therapies.

Authors

Andrea Angioi, Doloretta Piras, Nicola Lepori, Antonello Pani

Published in

Pediatric nephrology (Berlin, Germany). Oct 19, 2026. Epub Oct 19, 2026.

Abstract

Kidney vasculitides in children encompass a heterogeneous group of immune-mediated disorders with distinct pathogenic mechanisms but a shared risk of irreversible kidney injury. Although pediatric vasculitides are rare, advances in understanding disease biology, coupled with significant therapeutic developments in adult vasculitides, have reshaped treatment paradigms. This review summarizes current evidence for the acute-phase and maintenance treatment of pediatric kidney vasculitis and examines how emerging adult therapies, including B-cell depletion, complement inhibition, cytokine-directed agents, and treatment de-escalation strategies, may be responsibly adapted for use in children.

PMID:
42895572
Bibliographic data and abstract were imported from PubMed on 20 Oct 2026.

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