New insights into takotsubo syndrome: results from a multicenter cohort.

Authors

Hugo Lanz, Endrit Cekaj, Lucas Bacmeister, Christian Jung, Samuel Muli, Sabine Hoffmann, Matthias Schmid, Marcelo Galdos-Bejar, Daniel Hoyer, Lisa Crusius, Norman Mangner, Lisa Reinhardt, Loubna Yahsaly, Lars Michel, Victoria Pfeiffer, Mostafa Salem, Rafael Henrique Rangel, Johannes Terporten, Fabian Heindl, Marcus Brugger, Sebastian Zimmer, Tienush Rassaf, David Leistner, Dirk Westermann, Benjamin Meder, Malte Kelm, Stephan Baldus, Christian Schulze, Georg Nickenig, Franz Haertel, Enzo Lüsebrink

Published in

Clinical research in cardiology : official journal of the German Cardiac Society. Oct 19, 2026. Epub Oct 19, 2026.

Abstract

Takotsubo syndrome has long been deemed a benign condition following sudden emotional stress. While current mechanisms explaining the acute cardiac dysfunction are not fully understood, current evidence suggests certain takotsubo populations are at higher risk of adverse course. Acute neurologic emergencies commonly precede the takotsubo syndrome and new insights into the role of the brain-heart axis and central autonomic regions driving excess sympathetic activation have come about.
This multicenter analysis included 595 patients admitted between January 2013 and December 2024 with takotsubo syndrome across 13 German tertiary care centers. The aim of this study was to (I) assess whether acute brain pathology influences severity of cardiac dysfunction differently in comparison to other nonneurologic forms of physical or emotional stress, (II) investigate short-term recovery of cardiac function, and (III) improve identification of vulnerable patients susceptible to critical in-hospital course. Marginal odds ratios were estimated for cardiac complications of takotsubo syndrome across trigger groups using generalized estimating equations. Multivariable mixed-effects logistic regression models were fit to analyze the association between prespecified variables for short-term recovery of wall motion and systolic abnormalities as well as critical in-hospital course. Acute neurologic emergencies (47.5%) and common physical triggers (37.9%) were associated with higher risk of cardiac complications in takotsubo syndrome compared to emotional triggers (12.5%). Nonapical forms of takotsubo syndrome showed improved recovery of wall motion abnormalities (OR 2.70, 95% CI 1.34-5.45), while older patients had worse recovery of systolic function to discharge (OR 0.67, 95% CI 0.48-0.93). Conversely, younger male patients in which disease was triggered by neurologic emergencies or physical triggers presented with higher odds of critical in-hospital course.
Results of this study challenge the assumption of uniform reversibility of cardiac dysfunction and emphasize the need for early risk stratification and awareness of high-risk features as well as varying clinical presentations.

PMID:
42895542
Bibliographic data and abstract were imported from PubMed on 20 Oct 2026.

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