Image-guided focused ultrasound for non-invasive modulation of superficial and deep tissues.

Authors

Namrata Sangwan, N Chris Chaggares, Zahra Torbatian, Thomas Anthony Anderson

Published in

STAR protocols. Volume 7. Issue 4. Pages 104900. Oct 19, 2026. Epub Oct 19, 2026.

Abstract

Focused ultrasound (FUS) enables non-invasive, spatially precise modulation of biological tissues. This protocol describes assembly, calibration, and implementation of a diagnostic ultrasound-guided FUS (dUS-FUS) platform for real-time targeting of superficial and deep tissues in small-animal models. We demonstrate reversible sciatic nerve modulation in a rat acute pain model and assess sensory and motor functions using behavioral tests. The platform provides a reproducible workflow for image-guided tissue modulation and can be adapted to diverse preclinical applications. For complete details on the use and execution of this protocol, please refer to Sangwan et al.^1,2.

PMID:
42895854
Bibliographic data and abstract were imported from PubMed on 20 Oct 2026.

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