Authors
Sofiati Dian, Edison Johar, Diah Witari, Ida Yus Sriyani, Yora Permata Dewi, Ungke Antonjaya, Ahmad Rizal Ganiem, Frilasita Aisyah Yudhaputri, Reinout van Crevel, Sri Masyeni, Jeremy P Ledermann, Ann M Powers, Eric C Mossel, Khin Saw Aye Myint
Published in
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. Pages 109200. Oct 19, 2026. Epub Oct 19, 2026.
Abstract
To describe two cases of HPgV-1 identified during high-throughput sequencing (HTS)-based investigation of previously undiagnosed acute febrile illness (AFI) and central nervous system infection.
RNA metagenomic HTS was applied to clinical samples that had previously tested negative by PCR targeting alphaviruses, flaviviruses, enteroviruses, herpesviruses, and paramyxoviruses. Specimens were also tested for IgM antibodies against chikungunya virus, dengue virus, and Japanese encephalitis virus.
A complete HPgV-1 genotype 4 was recovered from a child with undifferentiated AFI. In a middle-aged man with HIV and severe neurological disorder, complete genomes of HPgV-1 (genotype 4), HPgV-2, and hepatitis C virus (genotype 3k) were identified.
To our knowledge, this is the first report of HPgV-2 detection in Indonesia, expanding its known geographic distribution. These findings underscore the complexity of viral co-infections in immunocompromised patients and the uncertain clinical significance of human pegiviruses. This further highlights the utility of metagenomic HTS for pathogen discovery and genomic surveillance in unexplained clinical syndromes.
PMID:
42896727
Bibliographic data and abstract were imported from PubMed on 20 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 6
- Comments 0