Gonad-soma inter-tissue communication alleviates ultraviolet-induced neurotoxicity in C. elegans.

Authors

Wenjing Zhang, Liu Ding, Shanpeng Qiao, Jiyu Xu, Qiyi Yi, Binmei Liu, Po Bian, Ting Wang

Published in

Cell communication and signaling : CCS. Volume 24. Issue 1. Jul 23, 2026. Epub Jul 23, 2026.

Abstract

Organismal genome stability is constantly challenged by endogenous and exogenous genotoxins, and DNA damage response (DDR) is a classical cell-autonomous mechanism for counteracting such damage. It remains unclear how somatic cells with DDR deficiencies maintain genomic integrity under stress. This study investigated whether inter-tissue communication, particularly from the reproductive system, coordinates DNA damage repair in repair-deficient cells. Using Caenorhabditis elegans, in which certain upstream DDR signaling components are transcriptionally repressed in somatic cells, we examined UV-induced neurotoxicity through behavioral assays (head thrashes, body bends, foraging, and salt chemotaxis). These deficits were associated with preferential impairment of dopaminergic, glutamatergic, and serotonergic reporter readouts, along with heterogeneous transcriptional remodeling of neurotransmitter pathway and pan-neuronal synaptic genes. Deficiencies in upstream DDR signaling (ATM/ATR), whether systemic or germline-specific, significantly exacerbated UV-induced neurobehavioral and transcriptional deficits. In contrast, germline-specific loss of nucleotide excision repair (NER) machinery had no significant effect, highlighting a unique inter-tissue signaling role for upstream DDR. Furthermore, CPR-4 was identified as a key mediator of this inter gonad-soma signaling. Germline DDR activation regulated cpr-4 expression, and loss of CPR-4 abolished UV-induced transcriptional activation of the somatic NER pathway and heightened behavioral sensitivity. Our study revealed a novel germline DDR to somatic tissue signaling axis essential for organismal stress resilience and proposed a new regulatory model centered on gonad-soma signaling.

PMID:
42897529
Bibliographic data and abstract were imported from PubMed on 20 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.