Authors
Gabriela Zdunek, Remigiusz Recław, Krzysztof Chmielowiec, Aleksandra Suchanecka, Ewelina Grywalska, Jolanta Chmielowiec, Dariusz Larysz, Anna Grzywacz
Published in
Postepy psychiatrii neurologii. Volume 35. Issue 2. Pages 161-169. Epub Sep 22, 2026.
Abstract
The objective of the study was to examine the association between COMT rs4680 genotypes, alcohol use disorder diagnosis, and differences in Five-Factor personality traits.
We examined 213 adult women in total, including 101 with a diagnosis of alcohol use disorder (AUD) and 112 non-addicted controls. All participants completed the NEO Five-Factor Inventory (NEO-FFI) and were genotyped for the COMT rs4680 polymorphism using real-time PCR. Group comparisons and genotype × diagnosis interactions were analyzed using ANOVA and post hoc tests.
Women with AUD scored significantly higher on Neuroticism and Openness to Experience, and lower on Extraversion, Agreeableness, and Conscientiousness compared to controls. A significant interaction between COMT rs4680 genotype and group status was observed for Openness (F2,207 = 6.16, p = 0.0025), with alcohol-dependent women carrying the G/A or G/G genotype showing elevated Openness scores compared to genotype-matched controls.
These findings suggest that dopaminergic genetic variation may moderate the expression of personality traits in the context of alcohol dependence. Openness to Experience, typically associated with cognitive flexibility, may represent both a vulnerability and an adaptation mechanism in addiction, depending on genetic background. This study emphasizes the importance of considering gene × personality interactions in female addiction research.
PMID:
42898859
Bibliographic data and abstract were imported from PubMed on 20 Oct 2026.
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