A New Frontier: Partial Cellular Reprogramming in Plastic Surgery.

Authors

Amir-Ala Mahmoud, Arman Fijany, Libby Copeland-Halperin, Granger Wong

Published in

Plastic and reconstructive surgery. Oct 20, 2026. Epub Oct 20, 2026.

Abstract

Partial cellular reprogramming employs Yamanaka factors to shift aging cells toward a younger epigenetic state without compromising cellular identity. Over two decades, this Nobel Prize winning breakthrough has advanced from the bench to a first in-human trial in 2026 for optic neuropathy and glaucoma. Here, we outline the foundation of partial cellular reprogramming and delineate its intersection with our field. Defined by innovation, plastic surgery can shape how partial reprogramming is applied in what may prove to be a transformative chapter for our specialty.

PMID:
42900571
Bibliographic data and abstract were imported from PubMed on 21 Oct 2026.

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