Buxubodines E-G: three new triterpenoidal alkaloids from Buxus bodinieri and their cardioprotective activity.

Authors

Xiao-Wei Yu, Jun-Qi Guo, Xin-Ying Song, Shuai-Long Li, Zhi-Xian Liu, Yin Nian, Shi-Ying Yuan, Hai-Bin Yuan

Published in

Journal of Asian natural products research. Pages 1-9. Oct 20, 2026. Epub Oct 20, 2026.

Abstract

Three new triterpenoidal alkaloids, buxubodines E-G (1-3), along with two known analogues, were isolated from the methanol extract of the leaves and twigs of Buxus bodinieri. Their structures, all featuring a 6/7/6/5 tetracyclic skeleton, were elucidated through comprehensive spectroscopic analysis, including 1D and 2D NMR (¹H-¹H COSY, HSQC, HMBC, and NOESY) and HRESIMS data. In bioassays of the new isolates, compound 2 demonstrated more potent protective effects against doxorubicin-induced injury in H9C2 cardiomyocytes compared with the positive control cyclovirobuxinum D.

PMID:
42900786
Bibliographic data and abstract were imported from PubMed on 21 Oct 2026.

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