A locally advanced PML::JAK1 myofibroblastic sarcoma arising in the neck.

Authors

Saeko Soejima, Jotaro Nakashima, Naoki Kojima, Miyako Kitazono, Dai Inoue, Shunji Takahashi, Haruka Okada

Published in

Virchows Archiv : an international journal of pathology. Oct 20, 2026. Epub Oct 20, 2026.

Abstract

A 54-year-old male patient presented with a painful right cervical mass encasing the common carotid artery. Histologically, the tumor consisted of polygonal to spindle-shaped cells with mild nuclear atypia and low mitotic activity (0-1/10 high-power fields). No myxoid stroma or necrosis was identified, and desmin expression was patchy. GenMineTOP, a dual DNA-RNA comprehensive genomic profiling system, revealed a PML exon 7-JAK1 exon 5 fusion. The tumor was surgically unresectable because of circumferential encasement of the right common carotid artery. After radiotherapy followed by doxorubicin chemotherapy, no distant metastases developed during 17 months of follow-up. PML::JAK1 myofibroblastic sarcomas have previously been reported in four abdominal cases, most of which showed aggressive behavior. This cervical case broadens the anatomic spectrum of PML::JAK1 myofibroblastic sarcomas to include the head and neck region and further expands their morphologic spectrum.

PMID:
42900368
Bibliographic data and abstract were imported from PubMed on 21 Oct 2026.

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