Accelerated Epigenetic Ageing in Diabetic Kidney Disease: A Comparison of 10 Epigenetic Clock Measures in Individuals With Type 1 Diabetes.

Authors

Claire Hill, Xiaoqi Luo, Anna Syreeni, Laura Smyth, Emma H Dahlström, Seamus Duffy, Jill Kilner, Abubakar Mangani, Alicia J Jenkins, Gareth McKay, Alexander P Maxwell, Eoin P Brennan, Catherine Godson, Joel N Hirschhorn, Jose C Florez, Per-Henrik Groop, Niina Sandholm, Amy Jayne McKnight, FinnDiane Study Group and the GENIE Consortium

Published in

Diabetes. Oct 20, 2026. Epub Oct 20, 2026.

Abstract

We investigated whether an association existed between epigenetic age acceleration (EAA) and diabetic kidney disease (DKD) in type 1 diabetes, using 10 clocks and two cohorts, and whether this amplified disease progression. Older EAA phenotypic age and shorter epigenetically predicted telomere lengths were significantly associated with DKD. Progression from normolbuminuria to severely increased albuminuria was associated with increased EAA, and age, epigenetic age, and EAA were significant predictors of progression to end-stage kidney disease. Results support the development of epigenetic biomarkers predicting DKD onset and progression.

PMID:
42900742
Bibliographic data and abstract were imported from PubMed on 21 Oct 2026.

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