Electrochemical Trifluoromethylation of Alkenes Using the Unpurified CF3I Reagent from Fluoroform.

Authors

Jiaming Cheng, Jinkun Fan, Chunhui Yang, Tengfei Pu, Qi Yang, Junyi Pan, Xu Cheng

Published in

The Journal of organic chemistry. Oct 21, 2026. Epub Oct 21, 2026.

Abstract

Fluoroform (HCF3) is an excess industrial gas with a significant greenhouse effect. The utilization of fluoroform as the trifluoromethyl precursor could turn the waste into a value-added product. In this work, we report a protocol for converting fluoroform to CF3I, which was used directly in the electrochemical trifluoromethylation of alkenes facilitated by the orthogonal reactivity in two steps. This protocol could give the trifluoromethylated products in comparable yield to those obtained with a commercial CF3I solution. In particular, the iodine residue in the prepared CF3I has a positive effect in some examples, with advantages over commercial CF3I reagents.

PMID:
42900866
Bibliographic data and abstract were imported from PubMed on 21 Oct 2026.

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