The next click in antibody drug conjugate development.

Authors

Avantika Gupta, Sarat Chandarlapaty

Published in

Cell reports. Medicine. Volume 7. Issue 10. Pages 103099. Oct 20, 2026.

Abstract

The clinical success of antibody drug conjugates has been shaped by the promise of delivering cytotoxic payloads precisely to tumors while minimizing systemic exposure. Simó and colleagues aim to improve on conventional ADC delivery by decoupling tumor localization from payload delivery to enhance pharmacokinetics and addressing antigen heterogeneity by enabling dual targeting.

PMID:
42901148
Bibliographic data and abstract were imported from PubMed on 21 Oct 2026.

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