Estimating GFR: what it is, what it is not, and why prediction cannot settle the question.

Authors

Pierre Delanaye, Rajiv Agarwal

Published in

Kidney international. Volume 110. Issue 5. Pages 1106-1108.

Abstract

Schultheiss et al. show that replacing Chronic Kidney Disease Epidemiology Collaboration with European Kidney Function Consortium cystatin C-based equations reclassifies women, but not men, into milder chronic kidney disease stages, while outcome prediction is unchanged. We argue that prediction of kidney failure cannot validate a glomerular filtration rate equation: dialysis initiation is a clinical decision, not a filtration measurement. The analysis is cross-sectional, leaving longitudinal performance untested. Equations are population tools; at the bedside, non-glomerular filtration rate determinants of both creatinine and cystatin C can mislead.

PMID:
42901688
Bibliographic data and abstract were imported from PubMed on 21 Oct 2026.

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